Older Australian Twins Study (OATS)

Older Australian Twin Study (OATS) – data collection began in 2007 and is ongoing in New South Wales and Victoria (data collection ran 2007-2016 in Queensland, based at the QIMR Berghofer Medical Research Institute) – analyses ongoing. This project was initiated by Perminder Sachdev (School of Psychiatry, University of New South Wales) and expanded to include researchers in Queensland and Victoria. The OATS investigative team comprises David Ames, Bernhard Baune, Henry Brodaty, John Crawford, Teresa Lee, Nick Martin, Karen Mather, Christopher Rowe, Perminder Sachdev, Katherine Samaras, Peter Schofield, Julian Trollor, Wei Wen, and Margie Wright, who directed the Queensland arm of the study. The study is longitudinal in design and investigates healthy brain ageing in older twins (65+ years, N = 623 at baseline). Measures collected include brain imaging and cognitive function, as well as genotypes. The study has formed collaborative partnerships with other twin and/or imaging studies around the world, including the ENIGMA (Enhancing Neuroimaging Genetics through Meta-Analysis) Consortium.

(Click here for more information on this project)

Key Publications

Lee, T., Mosing, M. A., Henry, J. D., Trollor, J. N., Ames, D., Martin, N. G., . . . Team, O. R. (2012). Genetic Influences on Four Measures of Executive Functions and Their Covariation with General Cognitive Ability: The Older Australian Twins Study (vol 42, pg 528, 2012). Behavior Genetics, 42(4), 539-540. https://doi.org/10.1007/s10519-012-9536-z

Lupton, M. K., Strike, L., Hansell, N. K., Wen, W., Mather, K. A., Armstrong, N. J., . . . Wright, M. J. (2016). The effect of increased genetic risk for Alzheimer’s disease on hippocampal and amygdala volume. Neurobiol Aging, 40, 68-77. https://doi.org/10.1016/j.neurobiolaging.2015.12.023

Sachdev, P. S., Lammel, A., Trollor, J. N., Lee, T., Wright, M. J., Ames, D., . . . team, O. r. (2009). A comprehensive neuropsychiatric study of elderly twins: the Older Australian Twins Study. Twin Res Hum Genet, 12(6), 573-582. https://doi.org/10.1375/twin.12.6.573

Wen, W., Thalamuthu, A., Mather, K. A., Zhu, W., Jiang, J., de Micheaux, P. L., . . . Sachdev, P. S. (2016). Distinct Genetic Influences on Cortical and Subcortical Brain Structures. Sci Rep, 6, 32760. https://doi.org/10.1038/srep32760